Biologics vs. Biosimilars: What You Need to Know

Biologic medications have transformed the treatment of many autoimmune and rheumatic diseases, helping patients regain quality of life and manage conditions more effectively. Recently, biosimilars have become an important part of the conversation, offering a potential alternative to biologics in certain cases. But what’s the difference between these two medications, and what should patients know before starting or switching treatment?

At Arthritis and Osteoporosis Treatment Center, our experienced team is here to guide you through your treatment options and ensure you have the information you need to make the best decisions for your care.

What Are Biologics?

Biologics are advanced medications created from living cells using cutting-edge technology. They are used to treat a variety of chronic conditions, including rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.

These medications target specific parts of the immune system that drive inflammation and disease activity, helping patients reduce symptoms, protect joints, and maintain mobility.

What Are Biosimilars?

A biosimilar is a medication designed to be highly similar—but not identical—to an existing biologic. Biosimilars are thoroughly studied and tested to confirm that they are just as safe and effective as the biologic they are modeled after.

Think of it like two buildings created from the same blueprint. They may have slightly different details, like paint color or doorknobs, but the overall structure and function are the same. In the same way, small differences between a biologic and a biosimilar do not change how the medicine works.

Biosimilars and biologics share the same:

• Safety and risk profile
• Effectiveness
• Dosage and strength

Biologics vs. Biosimilars: Frequently Asked Questions

Are biosimilars the same as generic drugs?

No. Generic drugs are exact copies of non-biologic medications. Biosimilars are close copies of biologics but still require extensive testing to ensure they perform the same.

Are biosimilars safe?

Yes. The FDA has a rigorous approval process to confirm biosimilars are safe, effective, and nearly identical to the original biologic.

Do all biologics have biosimilar options?

No. Only some biologic medications currently have biosimilars available for rheumatic diseases.

When should a patient consider a biosimilar?

The decision should always be made with your rheumatologist. In some cases, biosimilars may offer cost savings compared to biologics, but whether a biosimilar is right for you depends on your condition, treatment history, and insurance coverage.

AOTC’s Perspective

More recently, many insurance companies and pharmacy benefit managers (PBMs) are instituting biosimilar mandates, forcing coverage of these biosimilar drugs. We conduct prior authorizations to get approval for the biologics patients are currently stable on; however, sometimes insurance companies still will not provide coverage of the biologics. In these cases, we will be forced to switch to the biosimilar, and if it stops working, then re-evaluate treatment options.  

Switching medications without medical guidance can risk disease flare-ups or loss of treatment effectiveness; however, sometimes, despite prior authorizations and appeals, insurance companies do not give us a choice. While biosimilars may be appropriate for patients starting therapy for the first time, the decision should always be made together with your rheumatology team.

What Patients Can Do

Advocate for Yourself

Remember that medication changes are often influenced by insurance companies, not your doctor. If you feel strongly about your treatment plan, speak up.

Get Involved

Contact organizations like the Coalition of State Rheumatology Organizations (CSRO), which works to ensure patients have access to the highest quality care.

Talk to Your Rheumatologist

Never switch medications without professional guidance. Your doctor will help you understand the risks, benefits, and costs of each option.

Schedule an Appointment with Arthritis and Osteoporosis Treatment Center

At Arthritis and Osteoporosis Treatment Center, we are committed to helping you find the best treatment for your condition, whether that involves a biologic or a biosimilar. 

If you have questions about your medications or are considering a change, schedule an appointment with our team today. Together, we’ll create a treatment plan that prioritizes your health and long-term quality of life.