woman holding wrist with rheumatoid arthritis pain

Unusual Symptoms of Rheumatoid Arthritis

October 29, 2025
Arthritis

Rheumatoid arthritis (RA) is often associated with joint pain, stiffness, and swelling — but for many people, the early signs are far less obvious. Because RA is an autoimmune disease that affects the entire body, its symptoms can appear in unexpected ways, from fatigue and fevers to changes in the eyes or skin. Recognizing these early warning signs is key to managing the disease and protecting your long-term health.

At Arthritis & Osteoporosis Treatment Center, our rheumatology specialists understand that no two cases of RA are alike. We take time to listen, assess your symptoms, and create a treatment plan tailored to your needs — whether you’re newly diagnosed or managing ongoing flare-ups.

Unusual Symptoms of Rheumatoid Arthritis

Rheumatoid arthritis affects more than just your joints. Because inflammation can spread throughout the body, you may notice changes that don’t seem directly related to arthritis. Here are some unusual symptoms of rheumatoid arthritis to look out for:

1. Persistent Fatigue

Feeling unusually tired, even after a full night’s sleep, is one of the earliest signs of RA. Chronic inflammation can drain your energy long before joint pain begins.

2. Low-Grade Fevers

Frequent, mild fevers without an obvious cause can signal inflammation in the body — a common occurrence during active phases of RA.

3. Weight Loss or Decreased Appetite

RA can interfere with metabolism and appetite, leading to unintentional weight loss over time.

4. Morning Stiffness Lasting More Than 30 Minutes

Joint stiffness that lingers after waking up — especially in the hands, wrists, or knees — may indicate early-stage RA.

5. Dry Eyes and Mouth

Inflammation can affect tear and saliva glands, causing dryness or discomfort often linked to a related condition called Sjögren’s syndrome.

6. Skin Nodules

Firm lumps under the skin, especially around the elbows or fingers, can develop due to inflammation near joints.

7. Numbness or Tingling in the Hands and Feet

Inflamed joints can put pressure on surrounding nerves, leading to sensations similar to carpal tunnel syndrome.

8. Shortness of Breath

In some cases, RA affects the lungs, leading to scarring or inflammation that causes shortness of breath or chest discomfort.

9. Eye Redness or Pain

RA-related inflammation can impact the eyes, resulting in redness, light sensitivity, or blurred vision.

If you’ve experienced several of these symptoms — even without significant joint pain — it’s important to consult a rheumatologist for a proper diagnosis. Early treatment can prevent long-term joint and organ damage.

The Four Stages of Rheumatoid Arthritis

Understanding how rheumatoid arthritis progresses can help you and your doctor identify the best treatment options.

Stage 1: Early Inflammation

The lining of the joints becomes inflamed, causing mild pain or stiffness.

Stage 2: Joint Damage Begins

The cartilage that cushions joints starts to wear away, leading to increased discomfort.

Stage 3: Moderate to Severe Disease

Inflammation may damage bone and surrounding tissues, reducing range of motion.

Stage 4: Advanced RA

The joints lose function and mobility, and symptoms may persist even at rest.

Schedule an Appointment at Our Orange Park Office in Jacksonville, Florida

At Arthritis & Osteoporosis Treatment Center, we specialize in early detection and long-term management of rheumatoid arthritis. Our treatment options may include:

Prescription biologic or biosimilar medications
Lifestyle and nutrition recommendations
Infusion therapy
Physical therapy and mobility support

If you’ve noticed unusual symptoms or are seeking a trusted arthritis doctor in Jacksonville, FL, our experienced team is here to help. Schedule an appointment at our Orange Park office today to get started on a personalized treatment plan.